There’s something undeniably comforting about a warm, hearty casserole. It’s the kind of meal that brings people together, fills your kitchen with mouthwatering aromas, and makes dinner feel effortless.
Beyond their cozy appeal, casseroles are a lifesaver for busy days—they feed a crowd, make meal prepping a breeze, and require minimal cleanup (because who wants to do more dishes?).
But here’s the catch: traditional casseroles are often loaded with refined carbs and lacking in protein. The result? You’re hungry again before you know it, and that tempting dessert suddenly looks irresistible.
The good news? You don’t have to sacrifice flavor or satisfaction. High-protein casseroles are here to save the day! Packed with protein, they keep you fuller longer, curb cravings, and taste absolutely amazing.
To get you started, I’ve rounded up 15 delicious high-protein casserole recipes that are as nutritious as they are comforting. Ready to dig in? Let’s get cooking!
1. Chicken Broccoli Rice Casserole
This Chicken and Broccoli Rice Casserole is a simple, family-friendly dinner that comes together with just five ingredients.
It’s hearty, flavorful, and perfect for busy nights. With the help of a few shortcuts—like rotisserie chicken and cream of chicken soup—you can have a comforting meal on the table in about 30 minutes.
Best of all, everything bakes in a single dish, so there’s no need for extra bowls, pots, or pans—making cleanup a breeze!
Per Serving:
- Calories: 647
- Fats: 18g
- Protein: 55g
- Carbs: 64g
2. Spaghetti Squash Chorizo Breakfast Casserole
I need breakfast to be simple and fuss-free. This low-carb recipe, featuring spaghetti squash and spicy chorizo, is perfect for easy meal prep.
Packed with cheesy eggs, it’s a family favorite everyone loves! Check out more easy breakfast casserole ideas!
Per Serving:
- Calories: 261
- Fats: 5g
- Protein: 25g
- Carbs: 12g
3. Creamy Chicken and Wild Rice Casserole
If you’re in the mood for a warm, satisfying comfort meal, this easy chicken and wild rice casserole is sure to hit the spot.
It’s a family favorite—kid-approved and perfect for using up leftover chicken and rice!
Per Serving:
- Calories: 550
- Fats: 22g
- Protein: 32g
- Carbs: 53g
4. Harvest Chicken Casserole
This simple Harvest Chicken Casserole recipe features tender chicken breast, sweet potatoes, Brussels sprouts, and other comforting fall ingredients.
It’s a quick, wholesome, and nutritious dinner the whole family will love. Discover more cheap high protein meals!
Per Serving:
- Calories: 361
- Fats: 10g
- Protein: 39g
- Carbs: 30g
5. Mushroom Cheeseburger Casserole
This simple 7-ingredient casserole puts a low-carb, keto twist on the classic mushroom Swiss burger, with only 6g net carbs per serving.
Rich, savory mushrooms and seasoned ground beef blend perfectly with the bold, tangy taste of goat cheese, creating a comforting, crowd-pleasing dinner.
Per Serving:
- Calories: 540
- Fats: 35g
- Protein: 45g
- Carbs: 6.5g
6. Lazy Lasagna Casserole
I love casseroles—they’re simple to prepare, saving me time in the kitchen, while still being both nutritious and delicious—perfect for feeding a family.
This lasagna casserole is the ultimate choice for anyone craving a hearty, comforting meal without the hassle of long cooking hours. Best of all, it’s quick to make and doesn’t sacrifice flavor.
Per Serving:
- Calories: 449
- Fats: 22g
- Protein: 32g
- Carbs: 28g
7. Chicken Broccoli Cheese Quinoa Casserole
The Chicken Broccoli Cheese Quinoa Casserole offers a healthy twist on the classic comfort food, Chicken Broccoli and Rice Casserole.
Swapping out rice for high-protein, gluten-free quinoa, it keeps all the creamy, cheesy goodness while adding a nutritious boost.
Check out more low carb casserole recipes here!
Per Serving:
- Calories: 381
- Fats: 14g
- Protein: 29g
- Carbs: 36g
8. Chicken Parmesan Casserole
This chicken parmesan casserole offers a delicious twist on the classic Italian-American favorite.
It’s flavorful, cheesy, and wonderfully comforting—packed with protein and perfect for an easy, dump-and-bake meal.
Ideal for impressing guests or satisfying a hungry family, it delivers all the beloved flavors of chicken parmesan in half the time.
Discover more easy chicken casserole ideas!
Per Serving:
- Calories: 503
- Fats: 11g
- Protein: 37g
- Carbs: 61g
9. John Wayne Casserole
This simple yet satisfying casserole puts a tasty twist on the classic John Wayne recipe.
Packed with seasoned ground beef, bold taco flavors, and a generous layer of melted cheese, it’s both hearty and comforting.
Plus, it’s naturally low-carb and can be effortlessly adapted to be gluten-free or keto-friendly.
Per Serving:
- Calories: 590
- Fats: 48g
- Net Carbs: 5g
- Protein: 34g
10. Philly Cheesesteak Casserole
This simple Philly Cheesesteak Casserole packs all the iconic flavors of a classic Philly cheesesteak—tender sirloin steak, sautéed bell peppers, onions, and a blend of three cheeses!
Creamy, keto-friendly, and low-carb, it’s perfect for a satisfying dinner or a crowd-pleasing party snack.
Check out more low carb high protein casseroles!
Per Serving:
- Calories: 553
- Fats: 39g
- Carbs: 9g
- Protein: 42g
11. Instant Pot and Duo Crisp Chicken Casserole
Make a flavorful Chicken Casserole in the Instant Pot or Instant Pot Duo Crisp, using tender rotisserie chicken, egg noodles, crispy French’s onions, and a medley of vegetables.
It can also be prepared in the Ninja Foodi. Discover these 15 delicious high protein crockpot recipes here!
Per Serving:
- Calories: 300
- Fats: 17g
- Carbs: 17g
- Protein: 20g
12. Potato and Ground Beef Casserole
This Potato and Ground Beef Casserole with spinach is a hearty, all-in-one meal.
Packed with savory ground beef, tender potatoes, vibrant veggies, and creamy dairy, it’s a dinner you can serve on its own—no side dishes needed!
Best of all, there’s no potato peeling required, making it as easy as it is delicious.
Per Serving:
- Calories: 281
- Fats: 15g
- Carbs: 4g
- Protein: 31g
13. Eggplant Polenta Casserole
Whip up this Eggplant Polenta Casserole for a creative twist on vegetarian lasagna — swapping noodles for creamy polenta!
Packed with eggplant and mushrooms, it’s a hearty, veggie-filled dish that’s both flavorful and nutritious.
With just 15 minutes of prep, this casserole delivers all the comforting layers of lasagna with a unique and delicious spin.
Per Serving:
- Calories: 312
- Fats: 16g
- Carbs: 21g
- Protein: 23g
14. Classic Tuna Casserole
This Classic Tuna Casserole Recipe is a comforting blend of nostalgia and convenience. With fewer than eight ingredients, it’s perfect for busy weeknights.
A family favorite for years, it proudly holds its place in our collection of Easy Casserole Recipes!
Per Serving:
- Calories: 457
- Fats: 28g
- Carbs: 35g
- Protein: 16g
15. Cheesy Chicken Casserole
Cheesy Chicken Casserole — just 6 simple ingredients! Packed with pasta, tomatoes, and melted cheese, this quick and easy dinner is both hearty and irresistibly delicious.
Per Serving:
- Calories: 539
- Fats: 14g
- Protein: 45g
- Carbs: 58g
